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Beaumont Laboratory

Collagen Binding Activity (CBA) Profile

CBA, CBA Profile, Collagen-Binding Activity, vWF Collagen Binding Activity, von Willebrand Factor Collagen Binding Activity, LabCorp #500360, Esoterix # 300314, EPIC: LAB6242, SOFT: XCBA


This profile includes: won Willebrand Factor Collagen Binding Activity, von Willebrand Antigen, and Collagen Binding Ratio.

Specimen Collection Criteria

Collect: Two Light Blue-top Sodium Citrate tubes.


Physician Office/Drawsite Specimen Preparation

For optimal results, maintain whole blood specimen at room temperature (20-26°C or 68-78.8°F) prior to transport. Transport whole blood to the Laboratory within 4 hours of collection. If transport within 4 hours is not possible, the following procedure must be followed for accurate results:

  1. Centrifuge the capped tubes at 1500 x g for 15 minutes.
  2. Transfer plasma with plastic pipette into a plastic polypropylene centrifuge tube, cap and centrifuge an additional 15 minutes at 1500 x g to obtain platelet poor plasma (PPP) which has a platelet count less than 10 bil/L. Plasma with a platelet count of less than 10 bil/L is critical for accurate results.
  3. Immediately remove only the top two-thirds of the PPP and transfer into a plastic tube.
  4. Freeze (-20°C/-4°F or below) the PPP immediately.
  5. Transport frozen on DRY ICE. Specimen must remain frozen during transport.  

Preparation for Courier Transport

Transport: 1.0 mL PPP, frozen (-20°C/-4°F or below). (Min: 0.8 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 4 hours
Frozen (-20°C/-4°F or below): 60 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to LabCorp Esoterix Endocrinology, Calabassas Hills, CA, forwarded to Colorado Coagulation.


Results available in 3-8 days.

Reference Range

By report.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA), Calculation, LIA.

Clinical Utility

The collagen binding assay (CBA) can aid in the differentiation between von Willebrand disease type I and II when used in conjunction with the vWF antigen assay. This assay evaluates the ability of high molecular weight multimers present in the patient's sample to bind collagen which is coated on the microtiter plates.

CPT Code

83520, 85246.

Test Codes

LabCorp #500360, Esoterix # 300314, EPIC: LAB6242, SOFT: XCBA

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.