Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, Serum

MOG, ADEM antibody, MOG-IgG, NMO antibody, Optic Neuritis Antibody, Transverse Myelitis Antibody, Vision Loss Antibody, Myelin Oligodendrocyte Glycoprotein Fluorescence-Activated Cell Sorting (FACS) Assay, NMO Spectrum Disorder, LETM antibody, Optic Neuritis Antibody, ADEM antibody, NMOSD, Myelin Oligodendrocyte Glycoprotein Cell Sorting Assay

Test Codes

EPIC: LAB1232059, Beaker: MOG AB, Quest: 36952

Department

Send Outs

Instructions

Includes:
If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86362).

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes (SST).

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

• Serum separator tube (SST).
• Visible particular matter.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 7 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 21 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Quest Diagnostics, Wood Dale, IL.

Performed

Wednesday. 
Results available 3-7 days.

Reference Range

MOG Ab CBA, Serum	Negative
MOG Ab Titer, Serum	<1:10 titer

Test Methodology

Cell-based Immunofluorescence Assay

Interpretation

By report.

Clinical Utility

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, Serum – Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

CPT Codes

86362

Contacts

Last Updated

12/17/2025