800-551-0488

Lab results are too important to go anywhere else

Beaumont Laboratory

Creatinine Clearance, Blood and Urine

Antrim #19643, Adult Specimens: EPIC: LAB5442, SOFT: CRECL, Pediatric Specimens: EPIC: LAB5443, SOFT: CRCLP

Instructions

Specimen Collection Criteria

Collect: Blood AND Urine specimens.

  • Blood: One Gold-top SST tube.
  • Urine: 24 hour urine or timed specimen with no preservative.
  • Blood specimen must be collected within the time period from 24 hours prior to the start of urine collection thru 24 hours post completion of the urine collection.
  • Refer to the table of Urine Preservative Options when multiple tests are requested.
  • Keep 24 hour urine specimen iced or refrigerated during collection.
  • Include start and end dates and times for the collection period on the specimen container.
Urine Preservative Options
No Preservative
6N Hydrochloric Acid
Boric Acid (10g)
Sodium Carbonate
50% Acetic Acid
PREFERRED
Acceptable
Acceptable
Acceptable
Acceptable

Physician Office/Drawsite Specimen Preparation

  • Let SST specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged SST tube within two hours of collection. (Min: 0.5 mL)
  • Maintain urine specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Centrifuged SST tube and entire 24 hour or timed urine collection, refrigerated (2-8°C or 36-46°F).

Rejection Criteria

  • Moderate to grossly hemolyzed serum specimens.
  • Red-top tubes with serum not separated from cells within two hours of collection.
  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gel
Room temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gel
Room temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days

Urine Specimens

Room temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 4 days
Frozen (-20°C/-4°F or below): For longer storage.

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days (Royal Oak and Troy store an aliquot for 30 days.)

Laboratory

Farmington Hills Chemistry Laboratory.
Grosse Pointe Chemistry Laboratory.
Royal Oak Automated Chemistry Laboratory.
Troy Chemistry Laboratory.

Performed

Sunday - Saturday.
Results available within 24 hours. 

Reference Range

Creatinine Clearance: 70-140 mL/min.

Test Methodology

Spectrophotometry.

Interpretation

  • Creatinine clearance may be decreased in patients with:
    1. decreased renal blood flow due to congestive heart failure, shock, hemorrhage or dehydration.
    2. intrinsic renal disease such as nephrotic syndrome, glomerulonephritis, pyelonephritis or acute tubular disease.
    3. post-renal obstruction to urine flow.
    4. other causes such as multiple myeloma, adrenocortical hypofunction, hepatic failure, eclampsia and preeclampsia.
  • Creatinine clearance can be increased in pregnancy or in patients with high cardiac output, high protein diet, anemia, hypercatabolic states, and with exercise. Value decreases with advance in age.

Clinical Utility

Creatinine clearance is a renal function test used to estimate glomerular filtration rate (GFR).

CPT Code

82575.

Test Codes

Antrim #19643, Adult Specimens: EPIC: LAB5442, SOFT: CRECL, Pediatric Specimens: EPIC: LAB5443, SOFT: CRCLP

Last Updated

12/06/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.