CAH Profile 2
11 ß-hydroxylase deficiency , Congenital adrenal hyperplasia, 11-OH deficiency, LabCorp #500176, Esoterix #500835, EPIC: LAB5984, SOFT: XCAH2
- This profile includes: Androstenedione, Cortisol, Deoxycortisol (Specific Compound S), DHEA, Testosterone, 17-OH Progesterone.
- A number of drugs are known to influence endocrine function directly, or to interfere with assay methodology. Whenever possible, physicians should consider discontinuing all drugs, except those necessary to the patient's well-being, several days prior to sample collection. Always note any drugs being administered on the Test Request Form.
Specimen Collection Criteria
Collect: Two plain Red-top tubes.
Do not use Serum Separator Tubes.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within one hour of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.
Preparation for Courier Transport
Transport: 2.5 mL serum, frozen (-20°C/-4°F or below). (Min: 1.2 mL)
- Serum Separator (SST) tubes.
- Specimens not collected and processed as indicated.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 24 hours
Frozen (-20°C/-4°F or below): 90 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to LabCorp Esoterix Endocrinology, Calabassas Hills, CA.
Results available in 3-6 days.
High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS).
This assay aids in the diagnosis of congenital adrenal hyperplasia. 11 ß-hydroxylase (11-OH) deficiency is the second most common form of congenital hyperplasia. It is also associated with virilization, elevation of plasma androstenedione and DHEA-Sulfate, and hypertension.
Serum 11-Desoxycortisol is highly elevated in patients with adrenal hyperplasia due to 11-OH deficiency and provides the most useful marker for this disorder. Stimulation tests are usually not required in young infants, but may be useful in evaluating older patients who have either a late onset or were not diagnosed until later in life.
82157, 82533, 82626, 82634, 83498, 84403.
LabCorp #500176, Esoterix #500835, EPIC: LAB5984, SOFT: XCAH2
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.