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Beaumont Laboratory

UGT1A1 Genotyping for Gilbert/Irinotecan

UDP Glucuronosyltransferase 1A1 Genotyping, Gilberts, Irinotecan, ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT

Specimen Collection Criteria

Collect (preferred specimen): One Lavender-top EDTA or Yellow-top ACD tube.
Also acceptable: Extracted DNA (50 ng/mcL).

Note: This test should NOT be used for patients suspected of Crigler-Najjar syndrome.

Physician Office/Drawsite Specimen Preparation

Do not centrifuge. Maintain whole blood in original collection tubes, at refrigerated temperature (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 3.0 mL whole blood, at room temperature (20-26°C or 68-78.8°F). (Min: 1.0 mL)

Rejection Criteria

  • Centrifuged specimens.
  • Frozen specimens.
  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Thursday.
Results available in 3-8 days. 

Reference Range

By report.

Test Methodology

Polymerase Chain Reaction (PCR)/Fragment Analysis.

Interpretation

By report.

Clinical Utility

  • The genotyping test helps identify patients at risk for Irinotecan toxicity. UGT1A1 genotyping is also used for the diagnosis of Gilbert syndrome.
  • The test is recommended on patients to be treated with chemotherapy regimens including Irinotecan (Camptosar). The test is also recommended in patients with unconjugated hyperbilirubinemia.

CPT Code

81350.

Test Codes

ARUP: #51332, EPIC: LAB6927, SOFT: XGUGT

Last Updated

05/01/2017

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.