Lab Test

Pseudocholinesterase (PCHE)

Pseudocholinesterase

Test Codes

EPIC: LAB7173, SOFT: XTPCH, ARUP: 20167

Instructions

Specimen must be drawn prior to surgery or at least two days following surgery. Do not draw in the recovery room.

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 1.0 mL)

Also acceptable: One plain Red-top tube, or Lavender-top EDTA tube.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 0.5 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Rejection Criteria

Moderate to grossly hemolyzed specimens.

Specimen not collected and processed as indicated. 

In-Lab Processing

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F) within 4 hours of collection.

Transport: 0.5 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.1 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 hours.
Refrigerated (2-8°C or 36-46°F): 7 days.
Frozen (-20°C/-4°F or below): 3 months.

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday – Friday.
Results available in 2-6 days.

Reference Range

2,900 – 7,100 U/L.

Test Methodology

Quantitative enzymatic.

Interpretation

By report. Pseudocholinesterase is decreased following acute organophosphate poisoning. Use of red cell cholinesterase testing is also recommended for monitoring of organophophate exposure. In patients suspected of having a pseudocholinesterase variant, the Dibucaine Number test is also recommended.

Clinical Utility

Testing for pseudocholinesterase is used to monitor patient exposure to organophosphate insecticides, and aids in the identification of patients with an atypical gene and consequently a low level of cholinesterase that is not inhibited by dibucaine. Patients with this atypical gene are sensitive to the muscle relaxant succinylcholine since they are unable to hydrolyze it rapidly.

Pseudocholinesterase levels are decreased in chronic liver disease (particularly cirrhosis), acute hepatitis, acute infections, pulmonary emboli, chronic renal disease and pregnancy.

CPT Codes

82480.

Contacts

Last Updated

4/1/2020

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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.