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Organic Acid, Urine

Homogentisic Acid, Organic Acids Screen, Urine

Test Codes

EPIC: LAB6119, Beaker: XORGA, Mayo: OAU

Department

Send Outs

Specimen Collection Criteria

Collect: Random urine specimen in a screw-capped container (preferred) or other sterile urine container with no preservative. (Minimum: 4.0 mL)

Send specimen for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Freeze (-20°C/-4°F or below) specimen immediately after collection and prior to transport.

Preparation for Courier Transport

Transport: 10 mL urine, frozen (-20°C/-4°F or below). (Minimum: 4.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

• Maintain specimen frozen (-20°C/-4°F or below) prior to transport.
• Transport: 10 mL urine, frozen (-20°C/-4°F or below). (Minimum: 4.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 416 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday – Saturday.
Results available in 4-7 days.

Reference Range

By report.

Test Methodology

Gas Chromatography-Mass Spectrometry (GC-MS).

Interpretation

By report.

Clinical Utility

Organic acids are water-soluble compounds containing 1 or more carboxyl groups as well as other functional groups (-keto, -hydroxy). They occur as physiologic intermediates in a variety of metabolic pathways. The organic acidurias are a group of disorders in which one or more of these pathways are blocked, resulting in a deficiency of normal products and an abnormal accumulation of intermediate metabolites (organic acids) in the body. These excess metabolites are excreted in the urine and can be analyzed by capillary gas chromatography-mass spectrometry (GC-MS).

The incidence of individual inborn errors of organic acid metabolism varies from 1:10,000 to greater than 1:1,000,000 live births. Collectively, their incidence approximates 1:3,000 live births.

Reference

Mayo Test Catalog. Rochester, MN: Mayo Medical Laboratories, 2010.

CPT Codes

83919
LOINC:  2676-5

Contacts

Last Updated

10/2/2023