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Neisseria meningitidis Antibodies, IgG

Serogroups A, C, W-135, & Y, Neisseria meningitidis Tetravalent Antibodies, IgG, Meningococcal Serology, Meningitis Vaccine

Test Codes

EPIC: LAB6631, Beaker: XNMAB, ARUP: 2001603

Department

Send Outs

Instructions

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Also acceptable: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.25 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.25 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday.
Results available in 2-9 days.

Reference Range

N. meningitidis A, C, W-135, Y, IgG:

0.9 mcg/mL or less: Antibody concentration not protective.
1.0-2.0 mcg/mL: Equivocal.
2.1 mcg/mL or greater: Antibody to Neisseria meningitidis detected. Suggestive of protection.

Responder status is determined according to the ratio of the one-month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows:

1. If the one-month post-vaccination concentration is less than 3.0 mcg/mL, the patient is considered to be a non-responder.
2. If the one-month post-vaccination concentration is greater than or equal to 3.0 mcg/mL, a patient with a ratio of greater than or equal to 4.0 is a good responder, a ratio of 2.0-4.0 is a weak responder, and a ratio of less than 2.0 is considered a non-responder.

Test Methodology

Quantitative Multiplex Bead Assay.

CPT Codes

86741 x 4.

Contacts

Last Updated

10/8/2023