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Chlordiazepoxide Level (Librium and Metabolite)

Librium & Nordiazepam, Librium Level

Test Codes

EPIC: LAB5973, Beaker: XCDP, Mayo: CDP

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.

Note: Specimen must be protected from light.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum from cells within two hours of collection. Transfer serum to a LIGHT PROTECTED plastic transport tube and refrigerate (2-8°C or 36-46°).

Preparation for Courier Transport

Transport: 0.5 mL serum, refrigerate (2-8°C or 36-46°F). (Minimum: 0.3 mL)

Rejection Criteria

• Specimens not protected from light.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum from cells within two hours of collection. Transfer serum to a LIGHT PROTECTED plastic transport tube and refrigerate (2-8°C or 36-46°).

Transport: 0.5 mL serum or plasma, refrigerate (2-8°C or 36-46°F). (Minimum: 0.3 mL) 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Clinic Laboratories in Rochester, MN.

Performed

Monday and Wednesday.
Results available in 2-8 days.

Reference Range

By report.

Test Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry.

Interpretation

By report.

Clinical Utility

Chlordiazepoxide (Librium) is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. This assay is used to monitor the therapeutic drug level and to evaluate the toxicity of chlordiazepoxide. Nordiazepam is an active metabolite and is also monitored.

CPT Codes

80346, (Alt code: G0480).
LOINC:  Chlordiazepoxide 3457-9, Nordiazepam 13572-3

Contacts

Last Updated

9/12/2023